Introduction
For people managing histamine intolerance, DAO (diamine oxidase) supplements are often a go-to solution. But did you know that how you store these supplements—or even how they’re made—could affect how well they work?
A 2024 study by A. Guida, titled "Assessment of Resistance of Free and Encapsulated DAO to Temperature," explores how temperature exposure impacts the stability and effectiveness of DAO supplements. The findings might surprise anyone relying on DAO to manage their histamine-related symptoms.
Key Findings from the Study
1️⃣ Free vs. Encapsulated DAO
The study compared two types of DAO supplements:
Free DAO: The enzyme in its raw, unprotected form
Encapsulated DAO: DAO enclosed in a protective capsule designed to shield it from environmental factors
What They Found:
Encapsulated DAO was significantly more resistant to temperature changes than free DAO.
Free DAO lost a large portion of its enzyme activity when exposed to high temperatures, such as those experienced during shipping or improper storage.
Encapsulation techniques can protect the enzyme from heat, helping it remain active when it reaches the digestive system.
How Does This Affect You?
If you’re using DAO Enzyme Supplements to manage histamine intolerance, these findings suggest that:
✅ Storage conditions matter—keeping supplements in a cool, dry place can help preserve their effectiveness.
✅ Encapsulated DAO is more stable, especially if you live in a warm climate or if supplements are exposed to fluctuating temperatures during shipping.
✅ Check product labels for information about encapsulation technology or stability under heat.
Tips for Maximizing Effectiveness of DAO Enzyme Supplements
1️⃣ Store in a Cool, Dry Place:
Avoid leaving supplements in hot cars, near windows, or close to heat sources.
Some DAO products may benefit from refrigeration—check the label.
2️⃣ Choose Encapsulated Formulas:
Look for supplements labeled as “enteric-coated” or “encapsulated” for better stability.
3️⃣ Buy from Reputable Sources:
Ensure supplements are shipped in temperature-controlled packaging when possible, especially during hot seasons.
4️⃣ Check Expiry Dates:
Enzyme activity can decrease over time, particularly if not stored properly.
Final Thoughts
The effectiveness of your DAO supplements isn’t just about the dose—it’s about how well the enzyme survives before it reaches your body. Guida’s research shows that temperature exposure can significantly reduce DAO activity, but encapsulated supplements offer better protection.
If you’ve been wondering why your DAO supplements aren’t as effective as expected, storage conditions could be the missing piece.
Further Reading
Disclaimer
This blog post is for informational purposes only and presents findings from recent research on histamine intolerance. It is not intended as medical advice, diagnosis, or treatment. If you suspect histamine intolerance or have concerns about your health, consult a qualified healthcare professional.
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